Additional information

for medical professionals

Fact Sheet
This Fact Sheet answers questions around CatSper, the CatSper-Test, and the use of our product, the CatFlux buffer solutions.

Instructions for use
How to perform a CatSper-Test with CatFlux buffer solutions, based on the paper from Young et al., 2023. 

Material safety data sheets
for CatFlux buffers

General Terms and Conditions (GTC)
of Truion GmbH

Scientific background

  • Human Male Infertility Caused by Mutations in the CATSPER1 Channel Protein. Avenarius MR, Hildebrand MS, Zhang Y, Meyer NC, Smith LLH, Kahrizi K, Najmabadi H & Smith RJH (2009) Am J Hum Genet
    https://doi.org/10.1016/j.ajhg.2009.03.004

  • CATSPER2, a human autosomal nonsyndromic male infertility gene. Avidan N, Tamary H, Dgany O, Cattan D, Pariente A, Thulliez M, Borot N, Moati L, Barthelme A, Shalmon L, et al (2003) Eur J Hum Genet 11: 497–502
    https://doi.org/10.1038/sj.ejhg.5200991

  • Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity. Brown SG, Miller MR, Lishko P V., Lester DH, Publicover SJ, Barratt CLR & Da Silva SM (2018) Hum Reprod 33: 1812–1816
    https://doi.org/10.1093/humrep/dey278


  • A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. Luo T, Chen H, Zou Q, Wang T, Cheng Y, Wang H, Wang F, Jin Z, Chen Y, Weng S, et al (2019) Hum Reprod: 1–10
    https://doi.org/10.1093/humrep/dey377


  • The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Strünker T, Goodwin N, Brenker C, Kashikar ND, Weyand I, Seifert R & Kaupp UB (2011) Nature 471: 382–386
    https://doi.org/10.1038/nature09769

  • Patient with CATSPER3 mutations-related failure of sperm acrosome reaction with successful pregnancy outcome from intracytoplasmic sperm injection (ICSI). Wang J, Tang H, Zou Q, Zheng A, Li H, Yang S & Xiang J (2021) Mol Genet Genomic Med 9: 1–9
    https://doi.org/10.1002/mgg3.1579



  • Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa. Williams HL, Mansell S, Alasmari W, Brown SG, Wilson SM, Sutton KA, Miller MR, Lishko P V, Barratt CLR, Publicover SJ, et al (2015) Hum Reprod 30: 2737–2746
    https://doi.org/10.1093/humrep/dev243

  • Sensorineural deafness and male infertility: A contiguous gene deletion syndrome. Zhang Y, Malekpour M, Al-Madani N, Kahrizi K, Zanganeh M, Mohseni M, Mojahedi F, Daneshi A, Najmabadi H & Smith RJH (2007) J Med Genet 44: 233–240
    https://doi.org/10.1136/jmg.2006.045765